Anti-Angiopoietin 4抗体生成素4-ANGPTL4与小血管生成、肿瘤的转移有很重要的关系。

产品编号 byb-1087R
英文名称 Anti-Angiopoietin 4抗体
中文名称 血管生成素3/血管生成素4抗体
别    名 Angiopoietin 4; AGP4; ANG3; ANG-4; ANG 4; ANGPT4; AGP4; ANGP4_HUMAN.
Anti-Angiopoietin 4抗体
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  心血管  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ANGPT4 C-terminus
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Angiopoietin 4 is a glycosylated protein with a fibrinogen C terminal domain. It is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators.
Angiopoietin 4 is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. It may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described

Function:
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

Subunit:
Homodimer; disulfide-linked. Interacts with TEK/TIE2.

Subcellular Location:
Secreted (Probable). 

Tissue Specificity:
Highly expressed in the lung with much lower levels found in other tissues.

Similarity:
Contains 1 fibrinogen C-terminal domain.


血管生成素4-ANGPTL4与小血管生成、肿瘤的转移有很重要的关系。