Anti-ANGPTL2抗体主要分布于肾脏集合管上皮细胞基侧质膜,除了对水有通透性外、还可转运尿素和甘油等小分子物质,而尿素在尿液浓缩机制中有着重要的作用.

产品编号 yb-0537R
英文名称 Anti-ANGPTL2抗体
中文名称 血管生成素样蛋白2抗体
别    名 ANGPTL2; Angiopoietin like 2; Angiopoietin related protein 2; Angiopoietin-like protein 2; Angiopoietin-related protein 2; ANGL2_HUMAN; Angptl2; ANGL2; Arp2; HARP; MGC8889.
 Anti-ANGPTL2抗体  
说 明 书 0.1ml  0.2ml  
研究领域 肿瘤  心血管  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
细胞定位 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ANGPTL2 C-terminus
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
ANGPTL2/ANG-2 (Angiopoietin-like Protein 2) Induces sprouting in endothelial cells through an autocrine and paracrine action. [Subcellular location] Secreted. [Tissue specificity] Widely expressed in heart, small intestine, spleen and stomach. Also found in lower levels in colon, ovary, adrenal gland, skeletal muscle and in prostate. [PTM] N-glycosylated. [Similarity] Contains 1 fibrinogen C-terminal domain. ANGPTL2/ANG-2 (Angiopoietin-like Protein 2).


Function:
Induces sprouting in endothelial cells through an autocrine and paracrine action.

Subcellular Location:
Secreted.

Tissue Specificity:
Widely expressed in heart, small intestine, spleen and stomach. Also found in lower levels in colon, ovary, adrenal gland, skeletal muscle and in prostate.

Similarity:
Contains 1 fibrinogen C-terminal domain.

 
Ang1/2与血管生成关系zui为密切,目前有关该家族成员在肿瘤血管生成中的研究正日益增多。近年来也用于糖尿病导致的血管损伤研究也是热门课题.