Anti-F-Aromatase抗体细胞色素氧化酶p450; 是一种微粒体酶系统，催化睾酮经三步连续强化转变成17-β-雌二醇,在反应中睾酮作为激素原。

英文名称 Anti-F-Aromatase抗体
中文名称 芳香化酶抗体
别    名 Cytochrome p450 19A1; Estrogen synthetase; ARO 1; ARO; ARO1; CPV; CYPXIX; Cytochrome P450 19A1; Cytochrome P450 family 19 subfamily A polypeptide 1; MGC104309; P 450AROM; P450AROM; CP19A_HUMAN; Cytochrome P-450AROM.
Anti-F-Aromatase抗体  
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  神经生物学  信号转导  激酶和磷酸酶  合成与降解  
抗体来源 Mouse
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Aromatase N-terminus
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Aromatase is a key enzyme in steroidogenesis and plays an important role in sexual differentiation, oestrogen biosynthesis, fertility and carcinogenesis. It is highly conserved amongst mammals, and is highly expressed in placental tissue. Many environmental chemicals may influence aromatase activity and thereby disrupt endocrine function.

Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Subcellular Location:
Membrane; Peripheral membrane protein.

Tissue Specificity:
Brain, placenta and gonads.

DISEASE:
Aromatase excess syndrome (AEXS) [MIM:139300]: An autosomal dominant disorder characterized by increased extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual precocity in females. Note=The disease is caused by mutations affecting the gene represented in this entry. 
Aromatase deficiency (AROD) [MIM:613546]: A rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the cytochrome P450 family.


细胞色素氧化酶p450; 是一种微粒体酶系统，催化睾酮经三步连续强化转变成17-β-雌二醇,在反应中睾酮作为激素原。
细胞色素P450主要分布在内质网和线粒体内膜上，作为一种末端加氧酶，参与了生物体内的甾醇类激素合成等过程。
近年来，对细胞色素P450的结构、功能特别是对其在药物代谢中的作用的研究有了较大的进展。
研究表明细胞色素P450还是药物代谢过程中的关键酶，而且对细胞因子和体温调节都有重要影响。
芳香化酶-细胞色素P450作为和药物代谢及细胞因子相关的重要酶类，在药物代谢和免疫中起着相当重要的作用，对于它的研究将有助于新药的开发，并能帮助人们更加清楚的认识药物的代谢途径，在未来的新药中减少副作用，增加药物疗效。随着对细胞色素P450研究的深入，将有更多相关的药物代谢途径被发现，人们开发新药的视野将更加开阔，新药开发的速度也将加快，质量进一步提高。
鉴于P450的研究无论在理论上探索生物的生理代谢、选择进化和生物与环境的关系方面,或在环境保护、农业生态、生物防治、作物基因工程和医药卫生等应用方面,都有广泛的实践意义,因此,应该受到更大的关注和重视。