Anti-Adenosine A3 Receptor抗体（腺苷受体A3）属于G蛋白偶联受体家族，在腺苷调节细胞活力和生长中起关键作用，并且在很多肿瘤中表达增高，A3AR可能成为肿瘤诊断标志物和治疗靶点。

产品编号 yb-1225R
英文名称 Anti-Adenosine A3 Receptor抗体
中文名称 腺苷受体A3抗体
别    名 adenosine A3 receptor; A3AR; AD 026; AD026; ADORA 3; ADORA3; bA552M11.5; RP11 552M11.7; TGPCR1; adenosine receptor A3 isoform 1; adenosine receptor A3 isoform 2; AA3R_HUMAN.
 Anti-Adenosine A3 Receptor抗体  
说 明 书 0.1ml  0.2ml  
研究领域 心血管  神经生物学  细胞膜受体  G蛋白偶联受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADORA3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.

Subcellular Location:
Cell membrane.

Post-translational modifications:
Phosphorylation on Ser-317 may be crucial for rapid desensitization.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

 (腺苷受体A3)属于G蛋白偶联受体家族，在腺苷调节细胞活力和生长中起关键作用，并且在很多肿瘤中表达增高，A3AR可能成为肿瘤诊断标志物和治疗靶点。