Anti-Apolipoprotein D抗体是一个糖蛋白,它Z初是在人血浆的高密度脂蛋白中被分离出来的。apoD在结构上与其他类型的载脂蛋白存在很大的差异,被归入脂肪促成素家族。apoD可以与*、、*等多种疏水性小分子结合。

产品编号 yb-1254R
英文名称 Anti-Apolipoprotein D抗体
中文名称 载脂蛋白D抗体
别    名 Apolipoprotein D; APOD; APO D; APOD protein; APOD_HUMAN; Apolipoprotein D; Apo-D; ApoD.
Anti-Apolipoprotein D抗体  
说 明 书 0.2ml  
研究领域 肿瘤  心血管  细胞生物  免疫学  神经生物学  Alzheimer's  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 19kDa
细胞定位 分泌型蛋白 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human APOD
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
Apolipoprotein D (APO D), a glycoprotein involved in the human plasma lipid transport system. It is a progesterone binding glycoprotein of 24,000 dalton monomer molecular size, is a constituent of high density lipoprotein in plasma. The function of apolipoprotein D in the metabolism of plasma lipoproteins is unclear but the observation that this protein forms complexes with lecithin: cholesterol acyltransferase has led to the suggestion that apolipoprotein D may be involved in cholesterol esterification and transport of substrates and products of the reaction. Apolipoprotein D is expressed in a range of normal tissues including axillary apocrine glands, adrenal cortex and corpus luteum. Peripheral nerves, pituitary, testis, cerebellum and renal tubes are also positive. APO D was first isolated in large quantity as GCDFP 24, the major protein component of most human breast cyst fluids. In recent studies, Apo D immunoreactivity has been shown to be an early indicator of prostate cancer and advanced primary prostate tumors.
Function:
APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
Subunit:
Homodimer. In plasma, also exists as a disulfide-linked heterodimer with APOA2.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain tissue and tears.
Post-translational modifications:
N-glycosylatd. N-glycan heterogeneity at Asn-65: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); at Asn-98: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), dHex1Hex6HexNAc5 (minor) and dHex1Hex7HexNAc6 (minor).

载脂蛋白D(apolipoprotein D,apoD)是一个糖蛋白,它zui初是在人血浆的高密度脂蛋白中被分离出来的。apoD在结构上与其他类型的载脂蛋白存在很大的差异,被归入脂肪促成素家族。apoD可以与*、、*等多种疏水性小分子结合。

apoD在多种脊索动物的各类组织中广泛表达, 在脊椎动物中重要的生理功能。zui近的研究表明,apoD可以作为多种癌症及神经系统疾病的早期诊断标记, apoD是一个多配体、多功能的蛋白质.