Anti-FAM129B抗体May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.

产品编号 yb-8205R
英文名称 Anti-FAM129B抗体
中文名称 FAM129B蛋白抗体
别    名 chromosome 9 open reading frame 88; DKFZP434H0820; FAM129B; family with sequence similarity 129, member B; FLJ13518; FLJ22151; FLJ22298; hypothetical protein LOC64855; Meg 3; Meg-3; Meg3; Niban like protein 1; Niban-like protein 1; NIBL1_HUMAN; OC58; Protein FAM129B; bA356B19.6; C9orf88.
 Anti-FAM129B抗体  
说 明 书 0.2ml  
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 83kDa
细胞定位 细胞浆 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human FAM129B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. 

Subcellular Location:
Cytoplasm, cytosol. Cell junction, adherens junction. Note=In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during ophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation. 
 
Post-translational modifications:
Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane. 
As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases (PubMed:21148485).