Anti-FAIM1抗体FAIM1 （or Fas Apoptotic Inhibitory Molecule 1） is a recently discovered negative regulator of apoptosis.

产品编号yb-7061R
英文名称Anti-FAIM1抗体
中文名称 FAS凋亡抑制分子1抗体
别    名 FAIM 1; FAIM; Fas apoptotic inhibitory molecule 1; Fas apoptotic inhibitory molecule; FAIM1_HUMAN.
Anti-FAIM1抗体 
说 明 书 0.1ml  0.2ml  
研究领域 细胞生物  信号转导  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Zebrafish
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 20kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human FAIM1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
产品介绍 background:
FAIM1 (or Fas Apoptotic Inhibitory Molecule 1) is a recently discovered negative regulator of apoptosis. FAIM1 has no significant regions of homology to other gene products that modulate Fas killing. It plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. Overexpression of FAIM1 diminishes sensitivity to Fas mediated apoptosis of B and non B cell lines. FAIM1 is highly evolutionarily conserved and is widely expressed in murine tissues, suggesting that FAIM1 plays an important role in cellular physiology.

Function:
Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells (By similarity). 

Subcellular Location:
Cytoplasm (By similarity).

Similarity:
Belongs to the FAIM1 family.

Database links:
UniProtKB/Swiss-Prot: Q9NVQ4.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.